FOR2599Publications

2024

CCR3-dependent eosinophil recruitment is regulated by sialyltransferase ST3Gal-IV. Immler R, Nussbaumer K, Doerner A, El Bounkari O, Huber S, Abisch J, Napoli M, Schmidt S, Margraf A, Pruenster M, Rohwedder I, Lange-Sperandio B, Mall MA, de Jong R, Ohnmacht C, Bernhagen J, Voehringer D, Marth JD, Frommhold D, Sperandio M. Proc Natl Acad Sci U S A. 2024 May 7;121(19):e2319057121. doi: 10.1073/pnas.2319057121. Epub 2024 Apr 30. PMID: 38687790; PMCID: PMC11087806.

Genomic deletion of Bcl6 differentially affects conventional dendritic cell subsets and compromises Tfh/Tfr/Th17 cell responses. Xiao H, Ulmert I, Bach L, Huber J, Narasimhan H, Kurochkin I, Chang Y, Holst S, Mörbe U, Zhang L, Schlitzer A, Pereira CF, Schraml BU, Baumjohann D, Lahl K. Nat Commun. 2024 Apr 30;15(1):3554. doi: 10.1038/s41467-024-46966-6. PMID: 38688934; PMCID: PMC11061177.

The atypical IκB family member Bcl3 determines differentiation and fate of intestinal RORγt+ regulatory T-cell subsets. Köhler A, Geiselhöringer AL, Kolland D, Kreft L, Wichmann N, Hils M, Pasztoi M, Zurkowski E, Vogt J, Kübelbeck T, Biedermann T, Schmitz I, Hansen W, Kramer D, Gaida MM, Schmidt-Weber CB, Hoevelmeyer N, Ohnmacht C. Mucosal Immunol. 2024 Apr 23:S1933-0219(24)00039-4. doi: 10.1016/j.mucimm.2024.04.002. Epub ahead of print. PMID: 38663461.

Integrin β1-mediated mast cell immune-surveillance of blood vessel content. Link K, Muhandes L, Polikarpova A, Lämmermann T, Sixt M, Fässler R, Roers A. J Allergy Clin Immunol. 2024 Apr 16:S0091-6749(24)00362-2. doi: 10.1016/j.jaci.2024.03.022. Epub ahead of print. PMID: 38636606.

IgE and anaphylaxis specific to the carbohydrate alpha-gal depend on IL-4. Hils M, Hoffard N, Iuliano C, Kreft L, Chakrapani N, Swiontek K, Fischer K, Eberlein B, Köberle M, Fischer J, Hilger C, Ohnmacht C, Kaesler S, Wölbing F, Biedermann T. J Allergy Clin Immunol. 2024 Apr;153(4):1050-1062.e6. doi: 10.1016/j.jaci.2023.12.003. Epub 2023 Dec 21. PMID: 38135009; PMCID: PMC10997276.

Interleukin-10 enhances recruitment of immune cells in the neonatal mouse model of obstructive nephropathy. Wyczanska M, Thalmeier F, Keller U, Klaus R, Narasimhan H, Ji X, Schraml BU, Wackerbarth LM, Lange-Sperandio B. Sci Rep. 2024 Mar 6;14(1):5495. doi: 10.1038/s41598-024-55469-9. PMID: 38448513; PMCID: PMC10917785.

TGF-β specifies TFH versus TH17 cell fates in murine CD4+ T cells through c-Maf. Chang Y, Bach L, Hasiuk M, Wen L, Elmzzahi T, Tsui C, Gutiérrez-Melo N, Steffen T, Utzschneider DT, Raj T, Jost PJ, Heink S, Cheng J, Burton OT, Zeiträg J, Alterauge D, Dahlström F, Becker JC, Kastl M, Symeonidis K, van Uelft M, Becker M, Reschke S, Krebs S, Blum H, Abdullah Z, Paeschke K, Ohnmacht C, Neumann C, Liston A, Meissner F, Korn T, Hasenauer J, Heissmeyer V, Beyer M, Kallies A, Jeker LT, Baumjohann D. Sci Immunol. 2024 Mar;9(93):eadd4818. doi: 10.1126/sciimmunol.add4818. Epub 2024 Mar 1. Erratum in: Sci Immunol. 2024 May 31;9(95):eadp3365. doi: 10.1126/sciimmunol.adq3385. PMID: 38427718.

Comparative Metagenomic Analysis of Bacteriophages and Prophages in Gnotobiotic Mouse Models. Ishola OA, Kublik S, Durai Raj AC, Ohnmacht C, Schulz S, Foesel BU, Schloter M. Microorganisms. 2024 Jan 25;12(2):255. doi: 10.3390/microorganisms12020255. PMID: 38399658; PMCID: PMC10892684.

2023

Isolation of dermal adipocytes from mouse skin for biochemical analysis. Gehle PF, Satzinger S, Willenborg S, Eming SA. STAR Protoc. 2023 Dec 15;4(4):102765.doi: 10.1016/j.xpro.2023.102765. Epub 2023 Dec 7. PMID: 38060383; PMCID: PMC10751568.

Type 2 Immunity Regulates Dermal White Adipose Tissue Function. Satzinger S, Willenborg S, Ding X, Klose CSN, Radtke D, Voehringer D, Eming SA. J Invest Dermatol. 2023 Dec;143(12):2456-2467.e5. doi: 10.1016/j.jid.2023.05.017. Epub 2023 Jun 8. PMID: 37295491.

Tumor-derived prostaglandin E2 programs cDC1 dysfunction to impair intratumoral orchestration of anti-cancer T cell responses. Bayerl F, Meiser P, Donakonda S, Hirschberger A, Lacher SB, Pedde AM, Hermann CD, Elewaut A, Knolle M, Ramsauer L, Rudolph TJ, Grassmann S, Öllinger R, Kirchhammer N, Trefny M, Anton M, Wohlleber D, Höchst B, Zaremba A, Krüger A, Rad R, Obenauf AC, Schadendorf D, Zippelius A, Buchholz VR, Schraml BU, Böttcher JP. Immunity. 2023 Jun 13;56(6):1341-1358.e11. doi: 10.1016/j.immuni.2023.05.011. PMID: 37315536.

Guidelines for visualization and analysis of DC in tissues using multiparameter fluorescence microscopy imaging methods. Bayerl F, Bejarano DA, Bertacchi G, Doffin AC, Gobbini E, Hubert M, Li L, Meiser P, Pedde AM, Posch W, Rupp L, Schlitzer A, Schmitz M, Schraml BU, Uderhardt S, Valladeau-Guilemond J, Wilflingseder D, Zaderer V, Böttcher JP. Eur J Immunol. 2023 Nov;53(11):e2249923. doi: 10.1002/eji.202249923. Epub 2023 Jan 9. PMID: 36623939.

Granulocyte development, tissue recruitment, and function during allergic inflammation. Radtke D, Voehringer D. Eur J Immunol. 2023 Aug;53(8):e2249977. doi: 10.1002/eji.202249977. Epub 2023 Apr 4. PMID: 36929502.

Corrigendum: The aryl hydrocarbon receptor regulates lipid mediator production in alveolar macrophages. Maier AM, Huth K, Alessandrini F, Henkel F, Schnautz B, Arifovic A, Riols F, Haid M, Koegler A, Sameith K, Schmidt-Weber CB, Esser-von-Bieren J, Ohnmacht C. Front Immunol. 2023 Jun 5;14:1221064. doi: 10.3389/fimmu.2023.1221064. Erratum for: Front Immunol. 2023 Apr 04;14:1157373. doi: 10.3389/fimmu.2023.1157373. PMID: 37342341; PMCID: PMC10277851.

The aryl hydrocarbon receptor regulates lipid mediator production in alveolarmacrophages. Maier AM, Huth K, Alessandrini F, Schnautz B, Arifovic A, Riols F, Haid M, Koegler A, Sameith K, Schmidt-Weber CB, Esser-von-Bieren J,Ohnmacht C. Front Immunol. 2023 Apr 4;14:1157373. doi: 10.3389/fimmu.2023.1157373. Erratum in: Front Immunol. 2023 Jun 05;14:1221064. doi: 10.3389/fimmu.2023.1221064. PMID: 37081886; PMCID: PMC10110899.

2022

Guidelines for DC preparation and flow cytometry analysis of mouse nonlymphoid tissues. Probst HC, Stoitzner P, Amon L, Backer RA, Brand A, Chen J, Clausen BE, Dieckmann S, Dudziak D, Heger L, Hodapp K, Hornsteiner F, Hovav AH, Jacobi L, Ji X, Kamenjarin N, Lahl K, Lahmar I, Lakus J, Lehmann CHK, Ortner D, Picard M, Roberti MP, Rossnagel L, Saba Y, Schalla C, Schlitzer A, Schraml BU, Schütze K, Seichter A, Seré K, Seretis A, Sopper S, Strandt H, Sykora MM, Theobald H, Tripp CH, Zitvogel L. Eur J Immunol. 2023 Nov;53(11):e2249819. doi: 10.1002/eji.202249819. Epub 2022 Dec 13. PMID: 36512638.

Phosphatidylinositol 3-Kinase (PI3K) Orchestrates Aspergillus fumigatus-Induced Eosinophil Activation Independently of Canonical Toll-Like Receptor (TLR)/C-Type-Lectin Receptor (CLR) Signaling.Dietschmann A, Schruefer S, Westermann S, Henkel F, Castiglione K, Willebrand R, Adam J, Ruland J, Lang R, Sheppard DC, Esser-von-Bieren J, Radtke D, Krappmann S, Voehringer D. mBio. 2022 Aug 30;13(4):e0123922. doi: 10.1128/mbio.01239-22. Epub 2022 Jun 13. PMID: 35695427; PMCID: PMC9426586.

Th2 single-cell heterogeneity and clonal distribution at distant sites in helminth-infected mice. Radtke D, Thuma N, Schülein C, Kirchner P, Ekici AB, Schober K, Voehringer D. Elife. 2022 Aug 11;11:e74183. doi: 10.7554/eLife.74183.PMID: 35950748; PMCID: PMC9391044.

A novel monoclonal IgG1 antibody specific for Galactose-alpha-1,3-galactose questions alpha-Gal epitope expression by bacteria. Kreft L, Schepers A, Hils M, Swiontek K, Flatley A, Janowski R, Mirzaei MK, Dittmar M, Chakrapani N, Desai MS, Eyerich S, Deng L, Niessing D, Fischer K, Feederle R, Blank S, Schmidt-Weber CB, Hilger C, Biedermann T, Ohnmacht C. Front Immunol. 2022 Aug 5;13:958952. doi: 10.3389/fimmu.2022.958952. PMID: 35990627; PMCID: PMC9391071.

Thermosensitive PLGA-PEG-PLGA Hydrogel as Depot Matrix for Allergen-Specific Immunotherapy. Heine S, Aguilar-Pimentel A, Russkamp D, Alessandrini F, Gailus-Durner V, Fuchs H, Ollert M, Bredehorst R, Ohnmacht C, Zissler UM, Hrabě de Angelis M, Schmidt-Weber CB, Blank S. Pharmaceutics. 2022 Jul 22;14(8):1527. doi: 10.3390/pharmaceutics14081527. PMID: 35893787; PMCID: PMC9329805.

NF-κB in control of regulatory T cell development, identity, and function. Hövelmeyer N, Schmidt-Supprian M, Ohnmacht C. J Mol Med (Berl). 2022 Jul;100(7):985-995. doi: 10.1007/s00109-022-02215-1. Epub 2022 Jun 8. PMID: 35672519; PMCID: PMC9213371.

Isolation of macrophages from mouse skin wounds for single-cell RNA sequencing. Willenborg S, Roscito JG, Gerbaulet A, Roers A, Dahl A, Eming SA, Reinhardt S. STAR Protoc. 2022 Apr 19;3(2):101337. doi: 10.1016/j.xpro.2022.101337. Erratum in: STAR Protoc. 2022 Sep 16;3(3):101488. doi: 10.1016/j.xpro.2022.101488. PMID: 35496783; PMCID: PMC9046999.

Lung Epithelial CYP1 Activity Regulates Aryl Hydrocarbon Receptor Dependent Allergic Airway Inflammation. Alessandrini F, de Jong R, Wimmer M, Maier AM, Fernandez I, Hils M, Buters JT, Biedermann T, Zissler UM, Hoffmann C, Esser-von-Bieren J, Schmidt-Weber CB, Ohnmacht C. Front Immunol. 2022 Jun 6;13:901194. doi: 10.3389/fimmu.2022.901194. PMID: 35734174; PMCID: PMC9207268.

Macrophages acquire a TNF-dependent inflammatory memory in allergic asthma. Lechner A, Henkel FDR, Hartung F, Bohnacker S, Alessandrini F, Gubernatorova EO, Drutskaya MS, Angioni C, Schreiber Y, Haimerl P, Ge Y, Thomas D, Kabat AM, Pearce EJ, Ohnmacht C, Nedospasov SA, Murray PJ, Chaker AM, Schmidt-Weber CB, Esser-von Bieren J. J Allergy Clin Immunol. 2022 Jun;149(6):2078-2090. doi: 10.1016/j.jaci.2021.11.026. Epub 2021 Dec 30. PMID: 34974067.

Tissue Niches Formed by Intestinal Mesenchymal Stromal Cells in Mucosal Homeostasis and Immunity. Pasztoi M, Ohnmacht C. Int J Mol Sci. 2022 May 6;23(9):5181. doi: 10.3390/ijms23095181. PMID: 35563571; PMCID: PMC9100044.

A common framework of monocyte-derived macrophage activation. Sanin DE, Ge Y, Marinkovic E, Kabat AM, Castoldi A, Caputa G, Grzes KM, Curtis JD, Thompson EA, Willenborg S, Dichtl S, Reinhardt S, Dahl A, Pearce EL, Eming SA, Gerbaulet A, Roers A, Murray PJ, Pearce EJ. Sci Immunol. 2022 Apr 15;7(70):eabl7482. doi: 10.1126/sciimmunol.abl7482. Epub 2022 Apr 15. PMID: 35427180.

Gene-selective transcription promotes the inhibition of tissue reparative macrophages by TNF. Dichtl S, Sanin DE, Koss CK, Willenborg S, Petzold A, Tanzer MC, Dahl A, Kabat AM, Lindenthal L, Zeitler L, Satzinger S, Strasser A, Mann M, Roers A, Eming SA, El Kasmi KC, Pearce EJ, Murray PJ. Life Sci Alliance. 2022 Jan 13;5(4):e202101315. doi: 10.26508/lsa.202101315. PMID: 35027468; PMCID: PMC8761491.

Siglec-F Promotes IL-33-Induced Cytokine Release from Bone Marrow-Derived Eosinophils Independently of the ITIM and ITIM-like Motif Phosphorylation. Westermann S, Dietschmann A, Doehler D, Castiglione K, Bochner BS, Voehringer D, Radtke D. J Immunol. 2022 Feb 1;208(3):732-744. doi: 10.4049/jimmunol.2100184. Epub 2022 Jan 7. PMID: 34996839; PMCID: PMC8852812.

E-Cadherin restricts mast cell degranulation in mice. Klewer T, Bakic L, Müller-Reichert T, Kiewisz R, Jessberger G, Kiessling N, Roers A, Jessberger R. Eur J Immunol. 2022 Jan;52(1):44-53. doi: 10.1002/eji.202049087. Epub 2021 Oct 20. PMID: 34606636.

Diversity of T Helper and Regulatory T Cells and Their Contribution to the Pathogenesis of Allergic Diseases. Ohnmacht C, Eyerich S. Handb Exp Pharmacol. 2022;268:265-296. doi: 10.1007/164_2021_486. PMID: 34247282.

2021

Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing. Willenborg S, Sanin DE, Jais A, Ding X, Ulas T, Nüchel J, Popović M, MacVicar T, Langer T, Schultze JL, Gerbaulet A, Roers A, Pearce EJ, Brüning JC, Trifunovic A, Eming SA. Cell Metab. 2021 Dec 7;33(12):2398-2414.e9. doi: 10.1016/j.cmet.2021.10.004. Epub 2021 Oct 28. PMID: 34715039.

Metabolic orchestration of the wound healing response.Eming SA, Murray PJ, Pearce EJ. Cell Metab. 2021 Sep 7;33(9):1726-1743. doi: 10.1016/j.cmet.2021.07.017. Epub 2021 Aug 11. PMID: 34384520.

Age-related changes in the local milieu of iinflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage. Barkaway A, Rolas L, Joulia R, Bodkin J, Lenn T, Owen-Woods C, Reglero-Real N, Stein M, Vázquez-Martínez L, Girbl T, Poston RN, Golding M, Saleeb RS, Thiriot A, von Andrian UH, Duchene J, Voisin MB, Bishop CL, Voehringer D, Roers A, Rot A, Lämmermann T, Nourshargh S. Immunity. 2021 Jul 13;54(7):1494-1510.e7. doi:10.1016/j.immuni.2021.04.025. Epub 2021 May 24. PMID: 34033752; PMCID: PMC8284598.

Basophils balance healing after myocardial infarction via IL-4/IL-13. Sicklinger F, Meyer IS, Li X, Radtke D, Dicks S, Kornadt MP, Mertens C, Meier JK, Lavine KJ, Zhang Y, Kuhn TC, Terzer T, Patel J, Boerries M, Schramm G, Frey N, Katus HA, Voehringer D, Leuschner F. J Clin Invest. 2021 Jul 1;131(13):e136778. doi: 10.1172/JCI136778. PMID: 34196299; PMCID: PMC8245180.

Physiology and pathology of eosinophils: Recent developments: Summary of the Focus Workshop Organized by DGAKI. Renz H, Bachert C, Berek C, Hamelmann E, Levi-Schaffer F, Raap U, Simon HU, Ploetz S, Taube C, Valent P, Voehringer D, Werfel T, Zhang N, Ring J. Scand J Immunol. 2021 Jun;93(6):e13032. doi: 10.1111/sji.13032. Epub 2021 Mar 11. PMID: 33624312.

Anti-ferroptotic mechanism of IL4i1-mediated amino acid metabolism. Zeitler L, Fiore A, Meyer C, Russier M, Zanella G, Suppmann S, Gargaro M, Sidhu SS, Seshagiri S, Ohnmacht C, Köcher T, Fallarino F, Linkermann A, Murray PJ. Elife. 2021 Mar 1;10:e64806. doi: 10.7554/eLife.64806. PMID: 33646117; PMCID: PMC7946422.

Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice. Papaioannou NE, Salei N, Rambichler S, Ravi K, Popovic J, Küntzel V, Lehmann CHK, Fiancette R, Salvermoser J, Gajdasik DW, Mettler R, Messerer D, Carrelha J, Ohnmacht C, Haller D, Stumm R, Straub T, Jacobsen SEW, Schulz C, Withers DR, Schotta G, Dudziak D, Schraml BU. Nat Commun. 2021 Jan 19;12(1):464. doi: 10.1038/s41467-020-20659-2. PMID: 33469015; PMCID: PMC7815729.

2020

Filaggrin deficient mice have a lower threshold for cutaneous allergen sensitization but do not develop spontaneous skin inflammation or atopy, Muhandes L, Pippel M, Chapsa M, Behrendt R, Ge Y, Dahl A,Yi B, Dalpke A, Winkler S, Hiller M, Beissert S, Jessberger R, Fallon PG, Roers A. BioRxiv 2020, doi: https://doi.org/10.1101/2020.09.11.293688

Innate Lymphoid Cell-Epithelial Cell Modules Sustain Intestinal Homeostasis. Diefenbach A, Gnafakis S, Shomrat O. Immunity. 2020, 52:452-463.

Enabling anti-tumor immunity by unleashing ILC2. Mattiola I, Diefenbach A. Cell Res. 2020, 30:461-462.

An anti-inflammatory eicosanoid switch mediates the suppression of type-2 inflammation by helminth larval products, de Los Reyes Jiménez M, Lechner A, Alessandrini F, Bohnacker S, Schindela S, Trompette A, Haimerl P, Thomas D, Henkel F, Mourão A, Geerlof A, da Costa CP, Chaker AM, Brüne B, Nüsing R, Jakobsson PJ, Nockher WA, Feige MJ, Haslbeck M, Ohnmacht C, Marsland BJ, Voehringer D, Harris NL, Schmidt-Weber CB, Esser-von Bieren J. Science Translational Medicine, 2020, 12(540)

Inflammatory macrophage memory in NSAID-exacerbated respiratory disease, Haimerl P, Bernhard U, Schindela S, Henkel FDR, Lechner A, Zissler UM, Pastor X, Thomas D, Cécil A, Ge Y, Haid M, Prehn C, Tokarz J, Heinig M, Adamski J, Schmidt-Weber CB, Chaker AM, Esser-von Bieren J J Allergy Clin Immunol 2020,(6) S0091-6749(20)30803-4

Immune serum-activated human macrophages coordinate with eosinophils to immobilize Ascaris suum larvae, Coakley G, Volpe B, Bouchery T, Shah K, Butler A, Geldhof P, Hatherill M, Horsnell WGC, Esser-von Bieren J, Harris NL. 2020 Parasite Immunol.; 42:e12728.

House dust mite drives pro-inflammatory eicosanoid reprogramming and macrophage effector functions. Henkel FDR, Friedl A, Haid M, Thomas D, Bouchery T, Haimerl P, de Los Reyes Jiménez M, Alessandrini F, Schmidt-Weber CB, Harris NL, Adamski J, Esser-von Bieren J Allergy,2020, 74:1090-1101.

Therapeutic Potential of the Intestinal Microbiota for Immunomodulation of Food Allergies. Kreft L, Hoffmann C, Ohnmacht C. Front Immunol. 2020, 11:1853.

Mast Cells Occupy Stable Clonal Territories in Adult Steady-State Skin. Weitzmann A, Naumann R, Dudeck A, Zerjatke T, Gerbaulet A, Roers A. J Invest Dermatol. 2020, :S0022-202X(20)31380-4.

Cancer metastasis linked to macrophage size, shape, and metabolism,Murray, P. J. Exp Med 2020 217.

Disabled Homolog 2 Controls Prometastatic Activity of Tumor-Associated Macrophages. Marigo I, Trovato R, Hofer F, Ingangi V, Desantis G, Leone K, De Sanctis F, Ugel S, Canè S, Simonelli A, Lamolinara A, Iezzi M, Fassan M, Rugge M, Boschi F, Borile G, Eisenhaure T, Sarkizova S, Lieb D, Hacohen N, Azzolin L, Piccolo S,Lawlor R, Scarpa A, Carbognin L, Bria E, Bicciato S, Murray PJ, Bronte V. Cancer Discov. 2020 Nov;10(11):1758-1773. doi: 10.1158/2159-8290.CD-20-0036. Epub 2020 Jul 10. PMID: 32651166.

On macrophage diversity and inflammatory metabolic timers, Murray, P. J. Nat Rev Immunol 2020, 20: 89-90.

The Role of Senescence in the Development of Nonalcoholic Fatty Liver Disease and Progression to Nonalcoholic Steatohepatitis. Papatheodoridi AM, Chrysavgis L, Koutsilieris M, Chatzigeorgiou A. Hepatology. 2020, 71:363-374.

Fate of Adipose Progenitor Cells in Obesity-Related Chronic Inflammation. Pyrina I, Chung KJ, Michailidou Z, Koutsilieris M, Chavakis T, Chatzigeorgiou A. Front Cell Dev Biol. 2020, 8:644.

Metabolic inflammation as an instigator of fibrosis during non-alcoholic fatty liver disease. Katsarou A, Moustakas II, Pyrina I, Lembessis P, Koutsilieris M, Chatzigeorgiou A. World J Gastroenterol. 2020, 26:1993-2011.

A randomized, double blind, placebo-controlled phase IIa clinical trial to evaluate the efficacy and safety of subcutaneous Dupilumab in localized scleroderma Eming SA, principle investigator, A randomized, double blind, placebo-controlled phase IIa clinical trial to evaluate the efficacy and safety of subcutaneous Dupilumab in localized scleroderma (DupiMorph)

Glutamine metabolism controls stem cell fate reversibility and long-term maintenance in the hair follicle. Kim CS#, Ding X#, Allmeroth K, Biggs LC, Kolenc OI, L’Hoest N, Chacón-Martínez CA, Edlich-Muth C, Giavalisco P, Quinn KP, Denzel, Eming SA* and Wickström SA*. Cell Metab. 2020, 32:629-642.

Epidermal mTORC2 controls lipid synthesis and filaggrin processing in epidermal barrier formation. Ding X, Willenborg, S, Bloch W, Wickström S, Wagle P, Brodesser S, Roers A, Jais A, Brüning JC, Hall MN, Rüegg M, Eming SA. J Allergy Clin Immunol. 2020, 145:283-300

Role of collagen XII in skin homeostasis and repair. Schönborn K, Willenborg S, Schulz J, Imhof T, Eming SA, Quondamatteo F, Brinckmann J, Niehoff A, Paulsson M, Koch M, Eckes B, and Krieg T. Matrix Biol. 2020, S0945-053X(20)30087-1

Triacylglycerol synthesis enhances macrophage inflammatory function. Castoldi A, Monteiro LB, van Teijlingen Bakker N, Sanin DE, Rana N, Corrado M, Cameron AM, Hässler F, Matsushita M, Caputa G, Klein Geltink RI, Büscher J, Edwards-Hicks J, Pearce EL, Pearce EJ. Nat Commun. 2020, 11:4107

Immunomodulation and Immune Escape Strategies of Gastrointestinal Helminths and Schistosomes. Wiedemann M, Voehringer D. Front Immunol. 2020, 11:572865

Identification of Murine Basophils by Flow Cytometry and Histology. Schwartz C, Voehringer D. Methods Mol Biol. 2020, 2163:367-375

The B-cell antigen receptor of IgE-switched plasma cells regulates memory IgE responses. Schmitt MER, Lutz J, Haase P, Bösl MR, Wienands J, Engels N, Voehringer D. J Allergy Clin Immunol. 2020, 146:642-651.e5

Th2 cells promote eosinophil-independent pathology in a murine model of allergic bronchopulmonary aspergillosis. Dietschmann A, Schruefer S, Krappmann S, Voehringer D. Eur J Immunol. 2020, 50:1044-1056

Modulation of the humoral immune response by constitutively active STAT6 expression in murine B cells. Haase P, Mokada-Gopal L, Radtke D, Voehringer D. Eur J Immunol. 2020, 50:558-567

2019

Mast cells drive IgE-mediated disease but might be bystanders in many other inflammatory and neoplastic conditions. Maurer M, Taube C, Schröder NWJ, Ebmeyer J, Siebenhaar F, Geldmacher A, Schubert N, Roers A. J Allergy Clin Immunol. 2019, 144:S19-S30.

RelB Deficiency in Dendritic Cells Protects from Autoimmune Inflammation Due to Spontaneous Accumulation of Tissue T Regulatory Cells, Andreas N, Potthast M, Geiselhöringer AL, Garg G, de Jong R, Riewaldt J, Russkamp D, Riemann M, Girard JP, Blank S, Kretschmer K, Schmidt-Weber C, Korn T, Weih F, Ohnmacht C. J Immunol 2019, 15;203:2602-2613.

Defining Dysbiosis in Inflammatory Bowel Disease. de Jong RJ, Ohnmacht C. Immunity. 2019 50,8-10.

Diabetes Impedes the Epigenetic Switch of Macrophages into Repair Mode. Knipper JA, Ding X, Eming SA. Immunity. 2019, 51:199-201.

Eosinophils Mediate Basophil-Dependent Allergic Skin Inflammation in Mice. Eberle JU, Radtke D, Nimmerjahn F, Voehringer D. J Invest Dermatol. 2019, 139(9):1957-1965.e2.

Selective expression of constitutively activated STAT6 in intestinal epithelial cells promotes differentiation of secretory cells and protection against helminths. Schubart C, Krljanac B, Otte M, Symowski C, Martini E, Günther C, Becker C, Daniel C, Voehringer D. Mucosal Immunol. 2019, 12:413-424.

Dendritic Cells Control Regulatory T Cell Function Required for Maintenance of Intestinal Tissue Homeostasis. Hilpert C, Sitte S, Arnold H, Lehmann CHK, Dudziak D, Mattner J, Voehringer D. J Immunol. 2019,203:3068-3077.

Th2 cell-derived IL-4/IL-13 promote ILC2 accumulation in the lung by ILC2-intrinsic STAT6 signaling in mice. Symowski C, Voehringer D. Eur J Immunol. 2019, 49:1421-1432.

RELMα-expressing macrophages protect against fatal lung damage and reduce parasite burden during helminth infection. Krljanac B, Schubart C, Naumann R, Wirtz S, Culemann S, Krönke G, Voehringer D. Sci Immunol. 2019,4:eaau3814.

2018

Innate lymphoid cells, mediators of tissue homeostasis, adaptation and disease tolerance. Branzk N, Gronke K, Diefenbach A. Immunol Rev. 2018, 286:86-101.

Innate Lymphoid Cells: 10 Years On. Vivier E, Artis D, Colonna M, Diefenbach A, Di Santo JP, Eberl G, Koyasu S, Locksley RM, McKenzie ANJ, Mebius RE, Powrie F, Spits H. Cell. 2018,174:1054-1066.

Although Abundant in Tumor Tissue, Mast Cells Have No Effect on Immunological Micro-milieu or Growth of HPV-Induced or Transplanted Tumors. Ghouse SM, Polikarpova A, Muhandes L, Dudeck J, Tantcheva-Poór I, Hartmann K, Lesche M, Dahl A, Eming S, Müller W, Behrendt R, Roers A. Cell Rep. 2018, 22(1):27-35.

Unimpaired Responses to Vaccination With Protein Antigen Plus Adjuvant in Mice With Kit-Independent Mast Cell Deficiency. Schubert N, Lisenko K, Auerbach C, Weitzmann A, Ghouse SM, Muhandes L, Haase C, Häring T, Schulze L, Voehringer D, Gunzer F, Müller W, Feyerabend TB, Rodewald HR, Dudeck A, Roers A. Front Immunol. 2018;9:1870.

Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation.Ding X, Willenborg S, Bloch W, Wickström SA, Wagle P, Brodesser S, Roers A, Jais A, Brüning JC, Hall MN, Rüegg MA, Eming SA. J Allergy Clin Immunol. 2020 ,145(1):283-300.e8.

Murine eosinophil development and allergic lung eosinophilia are largely dependent on the signaling adaptor GRB2. Willebrand R, Dietschmann A, Nitschke L, Krappmann S, Voehringer D. Eur J Immunol. 2018, 48:1786-1795.

Innate immune cells in the adipose tissue. Chung KJ, Nati M, Chavakis T, Chatzigeorgiou A. Rev Endocr Metab Disord. 2018,19:283-292.

Myeloid Cell-Restricted STAT3 Signaling Controls a Cell-Autonomous Antifibrotic Repair Program. Do NN, Willenborg S, Eckes B, Jüngst C, Sengle G, Zaucke F, Eming SA. J Immunol. 2018 Jul , 201:663-674.

Cellular networks in wound healing. Willenborg S, Eming SA. Science. 2018, 362:891-892.

Basophils Are Dispensable for the Control of a Filarial Infection. Hartmann W, Linnemann LC, Reitz M, Specht S, Voehringer D., Breloer M. Immunohorizons. 2018 2:296-304.

2017

A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity. Chung KJ, Chatzigeorgiou A, Economopoulou M, Garcia-Martin R, Alexaki VI, Mitroulis I, Nati M, Gebler J, Ziemssen T, Goelz SE, Phieler J, Lim JH, Karalis KP, Papayannopoulou T, Blüher M, Hajishengallis G, Chavakis T. Nat Immunol. 2017, 18:654-664.

Inflammation and metabolism in tissue repair and regeneration. Eming SA, Wynn TA, Martin P. Science. 2017, 356:1026-1030.