FOR2599Publications

2021

Metabolic orchestration of the wound healing response, Eming SA*, Murray P*, Pearce EJ*, Cell Metabolism (*corresponding authors, in press)

Predicitive framework for macrophage activation, Sanin DE * , Ge Y , Marinkovic E , Kabat AM, Castoldi A, Caputa G., Grzes KM, Curtis JD , Willenborg S , Dichtl S , Reinhardt S, Dahl A , Pearce EL* , Eming SA* , Gerbaulet A* , Roers A* , Murray P* and Pearce EJ*, bioRxiv (*corresponding authors, in press)

Basophils balance healing after myocardial infarction via IL-4/IL-13. Sicklinger F, Meyer IS, Li X, Radtke D, Dicks S, Kornadt MP, Mertens C, Meier JK, Lavine KJ, Zhang Y, Kuhn TC, Terzer T, Patel J, Boerries M, Schramm G, Frey N, Katus HA, Voehringer D, Leuschner F. J Clin Invest. 2021 Jul 1;131(13):e136778. doi: 10.1172/JCI136778.

Physiology and pathology of eosinophils: Recent developments: Summary of the Focus Workshop Organized by DGAKI. Renz H, Bachert C, Berek C, Hamelmann E, Levi-Schaffer F, Raap U, Simon HU, Ploetz S, Taube C, Valent P, Voehringer D, Werfel T, Zhang N, Ring J. Scand J Immunol. 2021 Jun;93(6):e13032. doi: 10.1111/sji.13032. Epub 2021 Mar 11.

Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage. Barkaway A, Rolas L, Joulia R, Bodkin J, Lenn T, Owen-Woods C, Reglero-Real N, Stein M, Vázquez-Martínez L, Girbl T, Poston RN, Golding M, Saleeb RS, Thiriot A, von Andrian UH, Duchene J, Voisin MB, Bishop CL, Voehringer D, Roers A, Rot A, Lämmermann T, Nourshargh S. Immunity. 2021 Jul 13;54(7):1494-1510.e7. doi: 10.1016/j.immuni.2021.04.025. Epub 2021 May 24.

2020

Muhandes L, Pippel M, Chapsa M, Behrendt R, Ge Y, Dahl A,Yi B, Dalpke A, Winkler S, Hiller M, Beissert S, Jessberger R, Fallon PG, Roers A. Filaggrin deficient mice have a lower threshold for cutaneous allergen sensitization but do not develop spontaneous skin inflammation or atopy, BioRxiv 2020, doi: https://doi.org/10.1101/2020.09.11.293688

Diefenbach A, Gnafakis S, Shomrat O. Innate Lymphoid Cell-Epithelial Cell Modules Sustain Intestinal Homeostasis.Immunity. 2020, 52:452-463.

Mattiola I, Diefenbach A. Enabling anti-tumor immunity by unleashing ILC2. Cell Res. 2020, 30:461-462.

de Los Reyes Jiménez M, Lechner A, Alessandrini F, Bohnacker S, Schindela S, Trompette A, Haimerl P, Thomas D, Henkel F, Mourão A, Geerlof A, da Costa CP, Chaker AM, Brüne B, Nüsing R, Jakobsson PJ, Nockher WA, Feige MJ, Haslbeck M, Ohnmacht C, Marsland BJ, Voehringer D, Harris NL, Schmidt-Weber CB, Esser-von Bieren J. An anti-inflammatory eicosanoid switch mediates the suppression of type-2 inflammation by helminth larval products, Science Translational Medicine, 2020, 12(540)

Haimerl P, Bernhard U, Schindela S, Henkel FDR, Lechner A, Zissler UM, Pastor X, Thomas D, Cécil A, Ge Y, Haid M, Prehn C, Tokarz J, Heinig M, Adamski J, Schmidt-Weber CB, Chaker AM, Esser-von Bieren J Inflammatory macrophage memory in NSAID-exacerbated respiratory disease, J Allergy Clin Immunol 2020,(6) S0091-6749(20)30803-4

Coakley G, Volpe B, Bouchery T, Shah K, Butler A, Geldhof P, Hatherill M, Horsnell WGC, Esser-von Bieren J, Harris NL. Immune serum-activated human macrophages coordinate with eosinophils to immobilize Ascaris suum larvae, 2020 Parasite Immunol.; 42:e12728.

Henkel FDR, Friedl A, Haid M, Thomas D, Bouchery T, Haimerl P, de Los Reyes Jiménez M, Alessandrini F, Schmidt-Weber CB, Harris NL, Adamski J, Esser-von Bieren J House dust mite drives pro-inflammatory eicosanoid reprogramming and macrophage effector functions. Allergy,2020, 74:1090-1101.

Kreft L, Hoffmann C, Ohnmacht C. Therapeutic Potential of the Intestinal Microbiota for Immunomodulation of Food Allergies.Front Immunol. 2020, 11:1853.

Weitzmann A, Naumann R, Dudeck A, Zerjatke T, Gerbaulet A, Roers A. Mast Cells Occupy Stable Clonal Territories in Adult Steady-State Skin. J Invest Dermatol. 2020, :S0022-202X(20)31380-4.

Murray, P. J. J Cancer metastasis linked to macrophage size, shape, and metabolism, Exp Med 2020 217.

Marigo, I., R. Trovato, F. Hofer, V. Ingangi, D. E. S. F, S. Ugel, S. Cane, A. Simonelli, A. Lamolinara, M. Iezzi, M. Fassan, M. Rugge, F. Boschi, G. Borile, T. Eisenhaure, S. Sarkizova, D. Lieb, N. Hacohen, L. Azzolin, S. Piccolo, R. Lawlor, A. Scarpa, L. Carbognin, E. Bria, S. Bicciato, P. J. Murray and V. The Disabled homolog 2 controls pro-metastatic activity of tumor-associated macrophages Bronte Cancer Discov 2020. In press

Murray, P. J. On macrophage diversity and inflammatory metabolic timers, Nat Rev Immunol 2020, 20: 89-90.

Papatheodoridi AM, Chrysavgis L, Koutsilieris M, Chatzigeorgiou A. The Role of Senescence in the Development of Nonalcoholic Fatty Liver Disease and Progression to Nonalcoholic Steatohepatitis. Hepatology. 2020, 71:363-374.

Pyrina I, Chung KJ, Michailidou Z, Koutsilieris M, Chavakis T, Chatzigeorgiou A. Fate of Adipose Progenitor Cells in Obesity-Related Chronic Inflammation. Front Cell Dev Biol. 2020, 8:644.

Katsarou A, Moustakas II, Pyrina I, Lembessis P, Koutsilieris M, Chatzigeorgiou A. Metabolic inflammation as an instigator of fibrosis during non-alcoholic fatty liver disease. World J Gastroenterol. 2020, 26:1993-2011.

Eming SA, principle investigator, A randomized, double blind, placebo-controlled phase IIa clinical trial to evaluate the efficacy and safety of subcutaneous Dupilumab in localized scleroderma (DupiMorph)

Kim CS#, Ding X#, Allmeroth K, Biggs LC, Kolenc OI, L’Hoest N, Chacón-Martínez CA, Edlich-Muth C, Giavalisco P, Quinn KP, Denzel, Eming SA* and Wickström SA*. Glutamine metabolism controls stem cell fate reversibility and long-term maintenance in the hair follicle. Cell Metab. 2020, 32:629-642.

Ding X, Willenborg, S, Bloch W, Wickström S, Wagle P, Brodesser S, Roers A, Jais A, Brüning JC, Hall MN, Rüegg M, Eming SA. Epidermal mTORC2 controls lipid synthesis and filaggrin processing in epidermal barrier formation. J Allergy Clin Immunol. 2020, 145:283-300

Schönborn K, Willenborg S, Schulz J, Imhof T, Eming SA, Quondamatteo F, Brinckmann J, Niehoff A, Paulsson M, Koch M, Eckes B, and Krieg T. Role of collagen XII in skin homeostasis and repair. Matrix Biol. 2020, S0945-053X(20)30087-1

Castoldi A, Monteiro LB, van Teijlingen Bakker N, Sanin DE, Rana N, Corrado M, Cameron AM, Hässler F, Matsushita M, Caputa G, Klein Geltink RI, Büscher J, Edwards-Hicks J, Pearce EL, Pearce EJ. Triacylglycerol synthesis enhances macrophage inflammatory function. Nat Commun. 2020, 11:4107

Wiedemann M, Voehringer D. Immunomodulation and Immune Escape Strategies of Gastrointestinal Helminths and Schistosomes.Front Immunol. 2020, 11:572865

Schwartz C, Voehringer D. Identification of Murine Basophils by Flow Cytometry and Histology. Methods Mol Biol. 2020, 2163:367-375

Schmitt MER, Lutz J, Haase P, Bösl MR, Wienands J, Engels N, Voehringer D. The B-cell antigen receptor of IgE-switched plasma cells regulates memory IgE responses.J Allergy Clin Immunol. 2020, 146:642-651.e5

Dietschmann A, Schruefer S, Krappmann S, Voehringer D. Th2 cells promote eosinophil-independent pathology in a murine model of allergic bronchopulmonary aspergillosis. Eur J Immunol. 2020, 50:1044-1056

Haase P, Mokada-Gopal L, Radtke D, Voehringer D. Modulation of the humoral immune response by constitutively active STAT6 expression in murine B cells.Eur J Immunol. 2020, 50:558-567

2019

Maurer M, Taube C, Schröder NWJ, Ebmeyer J, Siebenhaar F, Geldmacher A, Schubert N, Roers A. Mast cells drive IgE-mediated disease but might be bystanders in many other inflammatory and neoplastic conditions. J Allergy Clin Immunol. 2019, 144:S19-S30.

Andreas N, Potthast M, Geiselhöringer AL, Garg G, de Jong R, Riewaldt J, Russkamp D, Riemann M, Girard JP, Blank S, Kretschmer K, Schmidt-Weber C, Korn T, Weih F, Ohnmacht C. RelB Deficiency in Dendritic Cells Protects from Autoimmune Inflammation Due to Spontaneous Accumulation of Tissue T Regulatory Cells, J Immunol 2019, 15;203:2602-2613.

de Jong RJ, Ohnmacht C. Defining Dysbiosis in Inflammatory Bowel Disease. Immunity. 2019 50,8-10.

Knipper JA, Ding X, Eming SA. Diabetes Impedes the Epigenetic Switch of Macrophages into Repair Mode.Immunity. 2019, 51:199-201.

Eberle JU, Radtke D, Nimmerjahn F, Voehringer D. Eosinophils Mediate Basophil-Dependent Allergic Skin Inflammation in Mice. J Invest Dermatol. 2019, 139(9):1957-1965.e2.

Schubart C, Krljanac B, Otte M, Symowski C, Martini E, Günther C, Becker C, Daniel C, Voehringer D. Selective expression of constitutively activated STAT6 in intestinal epithelial cells promotes differentiation of secretory cells and protection against helminths. Mucosal Immunol. 2019, 12:413-424.

Hilpert C, Sitte S, Arnold H, Lehmann CHK, Dudziak D, Mattner J, Voehringer D. Dendritic Cells Control Regulatory T Cell Function Required for Maintenance of Intestinal Tissue Homeostasis. J Immunol. 2019,203:3068-3077.

Symowski C, Voehringer D. Th2 cell-derived IL-4/IL-13 promote ILC2 accumulation in the lung by ILC2-intrinsic STAT6 signaling in mice. Eur J Immunol. 2019, 49:1421-1432.

Krljanac B, Schubart C, Naumann R, Wirtz S, Culemann S, Krönke G, Voehringer D. RELMα-expressing macrophages protect against fatal lung damage and reduce parasite burden during helminth infection. Sci Immunol. 2019,4:eaau3814.

2018

Branzk N, Gronke K, Diefenbach A. Innate lymphoid cells, mediators of tissue homeostasis, adaptation and disease tolerance. Immunol Rev. 2018, 286:86-101.

Vivier E, Artis D, Colonna M, Diefenbach A, Di Santo JP, Eberl G, Koyasu S, Locksley RM, McKenzie ANJ, Mebius RE, Powrie F, Spits H. Innate Lymphoid Cells: 10 Years On. Cell. 2018,174:1054-1066.

Ghouse SM, Polikarpova A, Muhandes L, Dudeck J, Tantcheva-Poór I, Hartmann K, Lesche M, Dahl A, Eming S, Müller W, Behrendt R, Roers A. Although Abundant in Tumor Tissue, Mast Cells Have No Effect on Immunological Micro-milieu or Growth of HPV-Induced or Transplanted Tumors. Cell Rep. 2018, 22(1):27-35.

Schubert N, Lisenko K, Auerbach C, Weitzmann A, Ghouse SM, Muhandes L, Haase C, Häring T, Schulze L, Voehringer D, Gunzer F, Müller W, Feyerabend TB, Rodewald HR, Dudeck A, Roers A. Unimpaired Responses to Vaccination With Protein Antigen Plus Adjuvant in Mice With Kit-Independent Mast Cell Deficiency.Front Immunol. 2018;9:1870.

Ding X, Willenborg S, Bloch W, Wickström SA, Wagle P, Brodesser S, Roers A, Jais A, Brüning JC, Hall MN, Rüegg MA, Eming SA. Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation.J Allergy Clin Immunol. 2020 ,145(1):283-300.e8.

Willebrand R, Dietschmann A, Nitschke L, Krappmann S, Voehringer D. Murine eosinophil development and allergic lung eosinophilia are largely dependent on the signaling adaptor GRB2. Eur J Immunol. 2018, 48:1786-1795.

Chung KJ, Nati M, Chavakis T, Chatzigeorgiou A. Innate immune cells in the adipose tissue. Rev Endocr Metab Disord. 2018,19:283-292.

Do NN, Willenborg S, Eckes B, Jüngst C, Sengle G, Zaucke F, Eming SA. Myeloid Cell-Restricted STAT3 Signaling Controls a Cell-Autonomous Antifibrotic Repair Program. J Immunol. 2018 Jul , 201:663-674.

Willenborg S, Eming SA. Cellular networks in wound healing. Science. 2018, 362:891-892.

Hartmann W, Linnemann LC, Reitz M, Specht S, Voehringer D., Breloer M. Basophils Are Dispensable for the Control of a Filarial Infection. Immunohorizons. 2018 2:296-304.

2017

Chung KJ, Chatzigeorgiou A, Economopoulou M, Garcia-Martin R, Alexaki VI, Mitroulis I, Nati M, Gebler J, Ziemssen T, Goelz SE, Phieler J, Lim JH, Karalis KP, Papayannopoulou T, Blüher M, Hajishengallis G, Chavakis T. A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity. Nat Immunol. 2017, 18:654-664.

Eming SA, Wynn TA, Martin P. Inflammation and metabolism in tissue repair and regeneration. Science. 2017, 356:1026-1030.