FOR2599Project 4

Regulation of eosinophil functions in vivo

tdTomato expressing eosinophils (red) in mouse ear during IgE-mediated Chronic Allergic Inflammation. Arrow marks eosinophil in blood vessel.

Summary

Eosinophil granulocyte numbers can rapidly increase upon helminth infections with potential protective aspects or in allergic responses where they might cause severe pathology. Recent findings also link eosinophils to metabolic homeostasis, survival of plasma cells, IgA production, thermogenesis, tissue repair and anti-tumor responses. Therefore, work on this cell type with diverse functions bears potential to better understand fundamental questions in immunology and allergy.

In this program we are interested in the interplay of eosinophils with other cell types in type 2 immune responses and how eosinophil signaling, survival and potentially positioning is modulated i.e. by alarmins like IL33. As part of the program we were already able to show that murine eosinophil development and survival is dependent on the adaptor protein Grb2 that is involved in signaling downstream of the IL5-receptor and we want to perform similar analysis for various other receptors. Other aspects of eosinophil biology like changes in metabolism or wound healing will be analysed in close cooperation with other groups of the program.

By this we want to help decipher eosinophil functions and show potential options to modulate type 2 immune responses.